This satellite meeting will bring together basic scientists and clinical investigators from the international community to provide in-depth understanding and current knowledge concerning new conceptual insights into the CNS acting drugs, alcohol abuse, drugs of abuse and treatment of drug addiction.  Addiction to drugs and alcohol is increasingly becoming a worldwide trend in lifestyle  prevalent in rich and poor countries alike. Methamphetamine, Alcohol, Cocaine and MDMA are the most widely abused drugs in the Europe, United States, Central America, South America and Asian Countries.  These drugs are not only addictive but also known to cause neurotoxicity in human as well as laboratory animals including rodents and nonhuman primates. Precise cellular and molecular mechanism of addiction and neurochemical changes associated with drug-induced neurotoxicity remain unclear.  This meeting will address the following: 1) Role of Epigenetic, Proteomics and Metabonomics in Drug Addiction (Cocaine, Alcohol, METH), 2) Drugs of Abuse and Medication Development including Nicotine/cigarette smoking, 3) Novel neurobiological targets for the treatment of Alcoholism. 4) Substituted Amphetamines-induced Neurochemical Changes and Relationship to Neurotoxicity 5) Drug of Abuse and Imaging Brain Structure and Function, 6) GHB/Volatile Solvent/Inhalant Neurotoxicity. The format of the meeting will result in a useful exchange of information not only for neurochemists but also investigators from other disciplines.