8:00 – 2:00 Registration desk open

8:00 – 8:05: Welcome & Opening Remarks in Conference Room: George Koob

8:05 – 8:10: Travel Award Presentations: George Koob and Nick Gilpin

8:10 – 9:00: PLENARY I

Moderator: Michael Kuhar, Emory University (USA)

George Koob, Director, NIH/NIAAA, USA.


SESSION I: DRUG AND ALCOHOL EFFECTS ACROSS THE LIFESPAN

Moderator: Tiffany Wills (USA) 

9:00 – 9:20: Epigenome-wide association study (EWAS) of cocaine users. Rodrigo
Grassi-Oliveira, U. of Aarhus, DENMARK.

9:20 – 9:40: Binge-drinking during mature adulthood induces behavioral and biochemical indices of cognitive decline in C57BL/6J mice.
Karen Szumlinski, UCSB USA.

9:40 – 10:00: Early life adversity effects on reward-related behavior and drug intake in developing rats.
Millie Rincon-Cortes, U. of Texas at Dallas, USA.

10:00 – 10:20: Prenatal alcohol effects on amygdala function and maladaptive behaviors.
Marvin Diaz, SUNY Binghamton, USA.

10:20 – 10:40 AM COFFEE/TEA BREAK

SESSION II: TRANSCRIPTIONAL AND EPIGENETIC EFFECTS OF ALCOHOL ON END ORGANS.  

Moderators: Antonio Noronha (USA) and Mohammed Akbar (USA) 

10:40 – 11:00: Role of Chromatin Modifier Developmental Pluripotency Associated Factor 4 in Mediation of Fetal Alcohol Effects on Neuroendocrine System.
Dipak Sarkar, Rutgers University, USA.

11:00 – 11:20: RNA-seq analysis reveals mechanisms underlying binge ethanol-induced differential spleen atrophy in adolescent rats.
Sulie Chang, Seton Hall University, USA.

11:20 – 11:40: Adolescent binge drinking disrupts fMRI neuronal networks and cognition through epigenetic priming of neuroimmune signaling and silencing of cholinergic neurons.
Fulton Crews, UNC, USA.

11:40 – 12:00: Deciphering brain epitranscriptome: A new mechanism of adult psychopathology after adolescent alcohol exposure.
Subhash Pandey, University of Illinois-Chicago, USA. 

12:00 – 1:30 PM LUNCH

SESSION III: SUBSTANCE ABUSE AND EARLY DEVELOPMENT

Moderators: Anna Bukiya (USA) and Fernando Valenzuela (USA)

1:30 – 1:50: Fetal cerebral artery mitochondria as a target of maternal alcohol intoxication.
Anna Bukiya, U. of Tennessee HSC, USA.

1:50 – 2:10: Acute exposure to THC alters discrete components of neuromuscular junction transmission in larval zebrafish.
Declan Ali, U. of Alberta, CANADA.

2:10 – 2:30: Effects of prenatal alcohol exposure on behavior in mice with dopamine and microglia cell specific deletion of CB2R.
Ana Canseco-Alba, National Institute of Neurology and Neurosurgery, MEXICO.

2:30 – 2:50: Effects of developmental alcohol and cannabis exposure on cortical sensory processing.
Alex Medina, U. of Maryland, USA.

2:50 – 3:10 PM COFFEE/TEA BREAK 

SESSION IV: FLASH TALKS - STUDENT & POST-DOC

Moderator: Barbara Juarez, U. of Maryland, USA

3:10 – 3:19: Opioid-induced dysbiosis of maternal gut microbiota during gestation alters offspring gut microbiota and pain sensitivity.
Yaa Abu, U. of Miami, USA.

3:19 – 3:27: Cortical brain areas involved in contextual tolerance to fentanyl in male C57BL/6 mice.
Rosa Serrano, Yale University, USA.

3:27 – 3:36: Central Amygdala Neuronal Populations Control Opioid-Related Behavior: The Role of Glucocorticoids.
Lucas Tortorelli, NIH, USA.

3:36 – 3:45: Neonatal morphine exposure (NME) results in sustained alterations to the gut microbiome contributing to hypersensitivity to thermal pain in adolescence.
Danielle Antoine, U. of Miami, USA.

3:45 – 3:54: Opioid antagonism modulates oxytocin-induces anxiolytic-like behavior: Implications for treatment of substance use disorders.
Khalin E. Nisbett. NIH, USA.

3:54 – 4:03: Binge ethanol exposure in mouse equivalent to third trimester human pregnancy: Impact on neuronal function in the subiculum.
Katalina Lopez, U. of New Mexico, USA.

4:03 – 4:12: Effect of ketone esters on blood alcohol levels in rats and human.
Janaina Vendruscolo, NIH, USA.

4:12 – 4:21: Psilocybin modulation of a cognitive control nucleus.
Maxwell Madden, U. of Maryland, USA.

4:21 – 3:30: Cell-Type-Specific Analysis of Dopaminoceptive Neurons in Ventral Hippocampus in Cocaine Action.
Veronika Kondev, Mount Sinai University, USA.

4:30 – 4:39: Systemic inhibition of mTOR activity does not block the expression of incubated craving for methamphetamine or sucrose.
Fernando Cano, UCSB, USA.

4:39 – 4:48: CCL2 antagonist RS504393 reverses heroin-induced hyperalgesia and place aversion in adult male and female rats. 
Nadia Said, NIH, USA

4:48 – 4:59: Use of Social Media Platforms Among Cannabis Retailers in the United States.
Patricia Cavazos-Rehg, Washington U., USA

8:00 – 2:00 PM Registration desk open

8:00 – 9:00: PLENARY II

Moderator: Antonio Noronha, NIH/NIAAA (USA)

Associative and Sensorimotor Basal Ganglia Circuit Roles in Substance Use and Misuse.
David Lovinger, Intramural Scientific Director, NIH/NIAAA, USA.


SESSION V: RECENT INSIGHTS ON THE NEUROBIOLOGY OF STRESS EFFECTS ON ALCOHOL- AND COCAINE-RELATED BEHAVIORS

Moderator: Marcus Weera (USA)

9:00 – 9:20: Stress increases voluntary ethanol intake in mice with a history of chronic intermittent ethanol exposure.
Marcelo Lopez, MUSC, USA.

9:20 – 9:40: Lateral hypothalamus mediates stress-induced escalation of alcohol drinking.
Marcus Weera, Tufts U., USA.

9:40 – 10:00: Adult BNST stimulation promotes sex-specific negative affect-like behavior and parabrachial activation in mice with adolescent alcohol history.
Lucas Albrechet-Souza, LSU Health Sciences Center, USA.

10:00 – 10:20: Critical role of microglia in stress-induced neuroadaptations in accumbens core and cocaine seeking.
Constanza Garcia-Keller, Med. College of Wisconsin, USA. 

10:20 – 10:40 AM COFFEE/TEA BREAK

SESSION VI: EXPLORING MULTILEVEL VULNERABILITIES IN COCAINE ADDITION 

Moderators: Olivier George (USA) and Lieselot Carrette (USA) 

10:40 – 11:00: An autophagy-related protein Becn2 regulates cocaine reward behaviors via the brain dopaminergic system.
Ming Xu, U. of Chicago, USA.

11:00 – 11:20: Identification of gene variants that predict cocaine addiction-like behaviors in heterogeneous stock rats.
Olivier George, UCSD, USA.

11:20 – 11:40: Sex-specific differences in deltaFosB expression promotes neuroadaptation and cocaine self-administration in heterogeneous stock rats.
Philip Vieira, CSU Dominguez Hills, USA.

11:40 – 12:00: Role of Peli1 expression and microglia activation in cocaine self-administration in heterogeneous stock rats.
Ming-Lei Guo, Eastern Virginia Medical School, USA.

12:00 – 12:20: Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats.
Lieselot Carrette, UCSD, USA.

12:20 – 1:40 PM LUNCH BREAK

SESSION VII: THE INTERSECTION OF PAIN-RELATED BEHAVIORS AND SUBSTANCE USE DISORDERS. 

Moderator: Jose Moron-Concepcion (USA) 

1:40 – 2:00: Genetic and genomic analysis of mechanisms underlying ethanol-induced analgesia.
Michael Miles, VCU, USA

2:00 – 2:20: Oxytocin effect on hyperalgesia during alcohol dependence in rats.
Brendan Tunstall, UTHSC, USA.

2:20 – 2:40: Sex-dependent effect of pain on alcohol drinking behavior in rat models of AUD: role of the CeA-NAc dynorphin projection.
Lucia Hipolito, U. of Valencia, SPAIN.

2:40 – 2:50 AM COFFEE/TEA BREAK

2:50 – 3:10: Dissection of neural circuitry underlying pain-induced aversion leading to abnormal opioid intake.
Nicolas Massaly, UCLA, USA.

3:10 – 3:30: Sex Differences in the Adolescent Alcohol-Induced Hyperalgesia
Tiffany Wills, LSUHSC, USA.

3:30 – 3:50: Elevated dopamine D1/D2 receptor ratio in opioid use disorder recovery.
Peter Manza, NIH, USA.

3:50 – 4:10: Dissection of PAG connectivity during osteoarthritis progression for the investigation of potential networks related to opioid addiction.
Joyce da Silva, University of Maryland, USA.

4:10 – 5:00 PM IDARS BUSINESS MEETING
Led by Nick Gilpin and Barbara Juarez  

Conference Tour 

No Scheduled Conference activities 

SESSION VIII: ALCOHOL: FROM GENES TO THE CLINIC

Moderators: Adolf Pfefferbaum (USA) and Edith Sullivan (USA)

8:20 – 8:40: Transcriptomic mechanisms of chronic alcohol exposure.
Sean Farris, U. of Pittsburgh, USA.

8:40 – 9:00: A role for interleukin-33 in the neuroimmunophysiology of excessive alcohol intake.
Regina Mangieri, UT-Austin, USA.

9:00 – 9:20: BK channels enable differential interactions between alcohol and neurosteroids on cerebral artery function.
Alex Dopico, UTHSC, USA.

9:20 – 9:40: AUD and aging exert compounded untoward effects on regional thalamic volumes in people living with HIV infection.
Adolf Pfefferbaum, SRI, USA.

9:40 – 10:00 PM COFFEE/TEA BREAK 

SESSION IX: TARGETING PEPTIDE RECEPTORS FOR ADDICTION TREATMENT

Moderators: Giordano de Guglielmo (USA) and Roberto Ciccocioppo (ITALY) 

10:00 – 10:20: Stress effects on kappa opioid receptor responses in dopamine neurons projecting to the dorsal medial prefrontal cortex.
Elyssa Margolis, UCSF, USA.

10:20 – 10:40: The role of kappa opioid receptor-expressing cells in social defeat stress-escalated alcohol drinking.
Rajani Maiya, LSU Health Sciences Center, USA.

10:40 – 11:00: The role of N/OFQ signaling in a rat model of opioid use disorder.
Giordano de Guglielmo, UCSD, USA.

11:00 – 11:20: Coactivation of NOP and classical opioid receptor systems in opioid use disorder.
Roberto Ciccocioppo, University of Camerino, ITALY. 

11:20 – 11:40: Oxytocin signaling in the central amygdala contributes to its therapeutic potential in reducing alcohol consumption,
Howard Becker, MUSC, USA.

11:40 – 12:00: Hormone control of food versus drug choice behavior.
Tod Kippin, UCSB, USA.

12:00 - 1:30 PM LUNCH BREAK

SESSION X: CANNABINOIDS AND ENDOCANNABINOIDS 

Moderators: Emmanuel Onaivi (USA) and Prakash Nagarkatti (USA) 

1:30 – 1:50: Psychiatric Side Effects of the Cannabinoid CB1 Inverse Agonist SR141716 (Rimonabant) were Likely Predictable from Preclinical Animal Models.
Eliot Gardner, NIH, USA.

1:50 – 2:10: Cannabinoid CB2 receptor neuro-immune crosstalk in alcohol induced behavioral effects.
Emmanuel Onaivi, NIDA-NIH & William Paterson U., USA.

2:10 – 2:30: Role of anandamide in the attenuation of acute respiratory distress syndrome through induction of epigenetic pathways and regulation of dysbiosis.
Mitzi Nagarkatti, U. of South Carolina, USA.

2:30 – 2:50: Intracellular signaling of SR171416A – A CB1R inverse agonist/anatagonist evoked emesis in least shrew.
Nissar Darmani, Western U. of Health Sciences, USA.

2:50 – 3:10: Alcohol induced behavioral and immune perturbations are attenuated by activation of CB2 cannabinoid receptors.
Aaliyah Roberts, William Paterson U., USA.

3:10 – 3:30: Delta-8-tetrahydrocannabinol Attenuates Experimental Multiple Sclerosis Through Modulation of Gut Microbiota.
Prakash Nagarkatti, U. of South Carolina, USA.

3:30 - 3:40 PM COFFEE/TEA BREAK

SESSION XI: CORTICAL CIRCUIT CONTROL OF COGNITION AND ACTION IN ADDICTION.   

Moderator: Brian Mathur (USA) 

3:40 – 4:00: Transcranial magnetic stimulation of human PFC effects on behavioral outcomes in AUD patients.
Abraham Zangen, Ben Gurion University, ISRAEL.

4:00 – 4:20: Decoding Neuropeptide S Modulation of OFC-mediated Reward Seeking in an Oral Fentanyl Self Administration Task.
Kasey Girven, U. of Washington, USA.

4:20 – 4:40: Chronic alcohol drinking effects on PFC circuits in non-human primates.
Verginia Cuzon-Carlson, Oregon Health & Science University, USA.

4:40 – 5:00: Alcohol drinking is governed by anterior cingulate cortex-dependent arousal.
Rafiq Huda, Rutgers University, USA.

SESSION XII: ALCOHOL AND OPIOIDS: OVERDOSE, STRESS, AND TREATMENT.

Moderator: Leandro Vendruscolo (USA)

8:40 – 9:00: Understanding Fentanyl Lethality: Respiratory Depression and Potential Biomarkers of Addiction-like Behaviors.
Renata Marchette, NIDA, NIH, USA.

9:00 – 9:20: The role of central amygdala astrocytes in ethanol dependence.
Judson Chandler, MUSC, USA.

9:20 – 9:40: The Stress of Addiction: Dysregulation of Psycho-neuro-endocrine Systems in Alcohol and Opioid Dependence.
Leandro Vendruscolo, NIDA, NIH, USA.

9:40 – 10:00: A Proof-of-Concept Human Laboratory Study of a Selective Glucocorticoid Antagonist for Alcohol Use Disorder.
Barbara Mason, Scripps, USA.

10:00 – 10:20: KNX100: A Novel Clinical-Stage Small Molecule Showing Potential for Treating Opioid and Alcohol Use Disorders.
Michael Bowen, U. of Sydney, Australia.

10:20 - 10:40 AM COFFEE/TEA BREAK

SESSION XIII: CELLULAR CROSSTALK IN HIV AND DRUG ABUSE-MEDIATED INFLAMMATION.

Moderators: Shilpa Buch (USA) and Sabita Roy (USA) 

10:40 – 11:00: HIV and opiate-mediated AD and senescence in astrocytes.
Shilpa Buch, U. of Nebraska, USA.

11:00 – 11:20: HIV and Drugs of Abuse-Mediated Neuroinflammation: Role of miRNAs and inflammasomes.
Palsamy Periyasamy, U. of Nebraska, USA.

11:20 – 11:40: Neuroinflammatory overload in methamphetamine misuse and HIV infection.
Michael Toborek, U. of Miami, USA.

11:40 – 12:00: Single cell RNA sequencing of mouse amygdala under opioid dependent and withdrawal states.
Sabita Roy, U. of Miami, USA.

12:00 – 12:20: Lung and brain injury by alcohol and e-cigarettes: Common mechanisms and role of extracellular vesicles in organ crosstalk.
Yuri Persidsky, Temple University, USA.

12:20 – 12:30: CLOSING COMMENTS & DISCUSSION
George Koob, IDARS President

12:30 - 2:00 PM LUNCH 

2:00: CONFERENCE DISMISSED